In the treatment of neuromanni patients, from pus wounds of which the associated flora was sown (Staphylococcus aureus, hemolytic streptococcus, Escherichia coli), staphylococcus disappeared later than other species. But Proteus vulgaris, and Ps. aeruginosa the effect of the antibiotic was less pronounced; Combining it with colimycin or polymyxin M led to favorable results in all cases. In the course of treatment with neovymanin, pathogens sown from the foci showed changes in the size and shape of the colonies of staphylococci, the latter losing their bunching habit and the change in tinctorial properties. Morphological changes in the cells during the treatment with neomycin were also observed in the Pseudomonas aeruginosa and vulgar protein; the last on the 10th – 15th day of the application of the new lyman lost creeping growth, and in Ps. aeruginosa weakened the ability to pigment.
An investigation into the dynamics of the influence of the new Lyman on the regeneration of tissues showed that along with a decrease in the number of microbes, the growth of fresh granulations and epithelization increased.Cytological studies have shown that already on the 3rd – 5th day after the beginning of the application of the new manganin, macrophages appeared, in a large number of playblasts; phagocytosis increased; the number of regenerative cells gradually increased, degenerating – decreased. The intensification of regenerative processes was observed in all cases and corresponded to the dynamics of microflora, the clinical picture of the pathological process, which usually resulted in complete recovery by the 10th day, sometimes even earlier.
AF Burianov (1968) describes the use of neimannin in the complex treatment of neonatal mastitis (in 46 children). The author notes that in recent times the severe forms of mastitis caused by ayatibiothoracoresistant staphylococci, which are of the type of phlegmon of newborns, have become frequent. They are characterized by a sharp onset and rapid spread of the process, and necrosis of the skin and subcutaneous tissue may occur. Novoimanin was used by electrophoresis; after surgical intervention, the cavity was drained with tampons moistened in a new immanin solution (1% alcohol solution of neimannin was diluted 1:10 with 10% glucose solution). To prevent complications of the upper respiratory tract, novoymanin was used as an aerosol. After application of complex treatment on the second-third day, the temperature normalized, the general condition improved child.
At the same time, the wound was cleaned, granulations intensified, and the size of the wound decreased.Bacteriological study confirmed the clinical effect. The author considers the use of newiman in the complex treatment of neonatal mastitis an effective means of prevention and treatment. MN Kovalishin (1967) used the newimanin in 86 patients in the orthopedic and traumatological department. The drug was put under gypsum bandages to wounds in the form of lotions for a long time. At the same time, a good tissue regeneration was observed; skin irritation or other complications not noted. In the author’s opinion, the newimanin is a good auxiliary agent of local action in the complex treatment of patients.